Tunisian Journal of Emergency Medicine

MULTIVISCERAL DAMAGE FOLLOWING ACUTE METHOTREXATE INTOXICATION BY DOSING ERROR

Authors

  • Sirine Bouzid

    ,

  • Rim Karray

    CHU Habib Bourguiba Sfax , CHU Habib Bourguiba Sfax

  • Amine Abdelhedi

    ,

  • Fadhila Issaoui

    ,

  • Olfa Chakroun

    ,

  • Noureddine Rekik

    ,
DOI:
https://doi.org/10.0000/e7t9zv49
Keywords:
Methotrexate, intoxication, dosing error, multivisceral damage
Abstract

Background: Methotrexate (MTX) is a chemotherapeutic agent commonly used for the treatment of nonmalignant and malignant conditions. It remains the principal medication used to treat rheumatoid arthritis. High-dose MTX is known to cause significant injuries, including acute renal failure, hepatotoxicity, myelosuppression, and multiorgan failure.

Case presentation: Here we report a 65 years old female patient with rheumatoid arthritis who had developed oral and mucocutaneous ulceration after daily ingestion of MTX.

Conclusion: This case report highlights the importance of early follow-up and regular laboratory investigations of patients on methotrexate therapy.

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Published
31-03-2025
Issue
Vol. 3 No. 1 (2025): TJEM 2025: Vol.3 Issue 1
Section
Case Reports
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How to Cite

MULTIVISCERAL DAMAGE FOLLOWING ACUTE METHOTREXATE INTOXICATION BY DOSING ERROR . (2025). Tunisian Journal of Emergency Medicine, 3(1). https://doi.org/10.0000/e7t9zv49