Tunisian Journal of Emergency Medicine

MULTIVISCERAL DAMAGE FOLLOWING ACUTE METHOTREXATE INTOXICATION BY DOSING ERROR

Authors

  • Sirine Bouzid

  • Rim Karray

    CHU Habib Bourguiba Sfax

  • Amine Abdelhedi

  • Fadhila Issaoui

  • Olfa Chakroun

  • Noureddine Rekik

DOI:

https://doi.org/10.0000/e7t9zv49

Keywords:

Methotrexate, intoxication, dosing error, multivisceral damage

Abstract

Background: Methotrexate (MTX) is a chemotherapeutic agent commonly used for the treatment of nonmalignant and malignant conditions. It remains the principal medication used to treat rheumatoid arthritis. High-dose MTX is known to cause significant injuries, including acute renal failure, hepatotoxicity, myelosuppression, and multiorgan failure.

Case presentation: Here we report a 65 years old female patient with rheumatoid arthritis who had developed oral and mucocutaneous ulceration after daily ingestion of MTX.

Conclusion: This case report highlights the importance of early follow-up and regular laboratory investigations of patients on methotrexate therapy.

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Published

31-03-2025

Issue

Vol. 3 No. 1 (2025): TJEM 2025: Vol.3 Issue 1

Section

Case Reports

License

Copyright (c) 2025 Tunisian Journal of Emergency Medicine

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

How to Cite

MULTIVISCERAL DAMAGE FOLLOWING ACUTE METHOTREXATE INTOXICATION BY DOSING ERROR . (2025). Tunisian Journal of Emergency Medicine, 3(1). https://doi.org/10.0000/e7t9zv49

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