Beyond the Rash: The Fatal Consequences of Lyell Syndrome

Abstract

Lyell syndrome is a rare, unpredictable, severe, and potentially fatal disease. Diagnosis is primarily clinical, confirmed by pathological examination, and lacks specific biological abnormalities. Several drugs, including allopurinol, are implicated in its onset. Therapeutic management requires admission to an intensive care unit, ideally a specialized burns resuscitation unit, and is essentially symptomatic. Treatment focuses on analgesia, hydroelectrolytic resuscitation, nutritional support, wound care, infection prevention, psychological support, and social reintegration.